Deciding on an immunohistochemical panel

Transcription factors tend to be very highly expressed, even in poorly differentiated tumors. Examples include:

• SATB2 (esp. in lower GI mucosal/NET, cutaneous NET, bone, and BCOR-rearranged sarcomas)
• GATA-3 (breast)

Stains to determine oncologic treatment

• SCC:
  • PD-L1
• Lymphoma:
  • CD45, CD43 (R-CHOP)
• Melanoma
  • SOX10 (Anti-BRAF, checkpoint inhibitors)